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54,000-4,800,000\u7f8e\u5143\uff0c\u8fd9\u4f7f\u5f97\u4e24\u5e74\u671f\u7b5b\u67e5\u66f4\u52a0\u7ecf\u6d4e\u6709\u6548\u3002Ten Haaf\u7b49\u4eba\u8ba4\u4e3a\uff0c\u6bcf\u5e74\u8fdb\u884c\u80ba\u764c\u7b5b\u67e5\u66f4\u7ecf\u6d4e\u6709\u6548\uff0c\u4f46\u662f\u4f4e\u5f3a\u5ea6\u3001\u957f\u65f6\u95f4\u95f4\u9694\u7684\u7b5b\u67e5\u9879\u76ee\u4e5f\u53ef\u80fd\u662f\u6210\u672c\u6548\u76ca\u9ad8\u7684\uff0811\uff09\u3002<\/p>\n<p>\u4e3a\u4e86\u8bc4\u4f30\u5bb9\u79ef\u7b5b\u67e5\u7684\u91cd\u8981\u610f\u4e49\uff0c\u9700\u8981\u57fa\u4e8eNELSON\u5b9e\u9a8c\u7684\u6700\u7ec8\u7ed3\u679c\u8fdb\u884c\u5168\u65b0\u7684\u6210\u672c\u6548\u76ca\u5206\u6790\uff0812\uff09\uff0c\u7279\u522b\u662f\u9274\u4e8e\u00a0WCLC 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tab_id=&#8221;1579027097261-a9836689-886e&#8221;][vc_column_text]\u9664\u4e86\u7b5b\u67e5\u80ba\u764c\u8fd9\u4e2a\u4e3b\u8981\u7ed3\u8bba\u4e4b\u5916\uff0c\u8fd8\u6709\u4e00\u4e9b\u503c\u5f97\u5173\u6ce8\u7684\u5176\u4ed6\u76f8\u5173\u8bfe\u9898\uff1a\u5438\u70df\u5bfc\u81f4\u7684\u201c\u4e09\u5927\u201d\u75be\u75c5\uff08\u80ba\u764c\uff0cCOPD\uff0c\u51a0\u5fc3\u75c5\uff09\uff0c\u6212\u70df\u8ba1\u5212\u548c\u6027\u522b\u5dee\u5f02\u3002<\/p>\n<p><em>\u5728\u5355\u72ec\u4e00\u6b21<\/em><em>CT<\/em><em>\u6210\u50cf\u68c0\u67e5\u4e2d\u8bca\u65ad\u51fa\u56e0\u5438\u70df\u8bf1\u53d1\u7684\u4e09\u5927\u75be\u75c5\uff1a\u80ba\u764c\uff0c\u51a0\u5fc3\u75c5\u548c<\/em><em>COPD.<\/em><\/p>\n<p>\u51a0\u5fc3\u75c5\uff08CHD\uff09\u548c\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u4e0e\u80ba\u764c\u76f8\u540c\uff1a\u2460\u5b83\u4eec\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u90fd\u5f88\u9ad8\uff1b\u2461\u5b83\u4eec\u7684\u4ea7\u751f\u5747\u4e0e\u5438\u70df\u6709\u5173\uff1b\u2462\u5b83\u4eec\u5747\u53ef\u91c7\u7528\u751f\u7269\u6807\u8bb0\u7269\u6210\u50cf\u6280\u672f\u8fdb\u884c\u6d4b\u91cf\u3002\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4ee5\u662f\u2460\u7528\u4e8e\u8bca\u65ad\u80ba\u764c\u7684\u80ba\u7ed3\u8282\u4f53\u79ef\u500d\u589e\u65f6\u95f4\uff08VDT\uff09\uff1b\u2461\u7528\u4e8e\u8bca\u65ad\u51a0\u5fc3\u75c5\u7684\u51a0\u72b6\u52a8\u8109\u9499\u5316\uff1b\u2462\u7528\u4e8e\u8bca\u65adCOPD\u7684\u80ba\u6c14\u80bf\u6307\u6807\u3002<\/p>\n<p>\u5bf9\u8fd9\u4e09\u5927\u75be\u75c5\u800c\u8a00\uff0c\u65e9\u671f\u6cbb\u7597\u53ef\u4ee5\u51cf\u5c11\u751a\u81f3\u505c\u6b62\u4e0a\u8ff0\u4e09\u79cd\u75be\u75c5\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u4f7f\u5927\u91cf\u60a3\u8005\u5728\u4ecd\u53ef\u4ee5\u88ab\u6cbb\u6108\u7684\u9636\u6bb5\u5f97\u5230\u6cbb\u7597\u3002\u800c\u4e8b\u5b9e\u4e0a\uff0c\u4e0a\u8ff0\u75be\u75c5\u7684\u7edd\u5927\u6570\u60a3\u8005\u7684\u6cbb\u7597\u5747\u5df2\u7ecf\u592a\u665a\uff0c\u901a\u5e38\u5f00\u59cb\u4e8e\u4e34\u5e8a\u75c7\u72b6\u663e\u73b0\u4e4b\u540e\u3002\u5982\u679c\u80fd\u5728\u5c1a\u65e0\u4e34\u5e8a\u75c7\u72b6\u7684\u65f6\u5019\u786e\u8bca\uff0c 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[14]\u3002\u9664\u4e86\u51cf\u5c11\u80ba\u764c\u53d1\u75c5\u7387\u5916\uff0c\u6212\u70df\u8fd8\u4f1a\u5bf9\u5176\u4ed6\u5438\u70df\u76f8\u5173\u7684\u5065\u5eb7\u95ee\u9898\u4ea7\u751f\u6709\u76ca\u5f71\u54cd\uff0c\u5305\u62ec\u51a0\u5fc3\u75c5\u548cCOPD[15]\u3002\u80ba\u764c\u7b5b\u67e5\u548c\u6212\u70df\u7684\u7ed3\u5408\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u80ba\u764c\u6b7b\u4ea1\u7387[16]\uff0c\u5e76\u53ef\u6291\u5236\u5176\u4ed6\u5408\u5e76\u75c7\u72b6\u7684\u53d1\u751f\u6216\u53d1\u5c55\u3002\u6211\u4eec\u7684\u5efa\u6a21\u7814\u7a76\u4e5f\u5f97\u51fa\u4e86\u7c7b\u4f3c\u7ed3\u8bba[[17]\u3002<\/p>\n<p><em>\u6027\u522b\u5dee\u5f02<\/em><\/p>\n<p>\u80ba\u764c\u7b5b\u67e5\u53c2\u4e0e\u8005\u7684\u751f\u7406\u6027\u522b\u5f71\u54cd\u7b5b\u67e5\u7ed3\u679c\u3002NLST\u548cNELSON\u7814\u7a76\u5747\u8868\u660e\uff0c\u5bf9\u5973\u6027\u7b5b\u67e5\u8981\u6bd4\u7537\u6027\u66f4\u6709\u6548 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title=&#8221;\u672a\u6765\u7684\u6311\u6218\u6216\u7814\u7a76\u95ee\u9898\u662f\u4ec0\u4e48\uff1f  &#8221; 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title=&#8221;4-IN-THE-LUNG-RUN&#8221; tab_id=&#8221;1579027105992-e39d95c8-66cc&#8221;][vc_column_text]NELSON\u7814\u7a76\u663e\u793a\u4e86\u80ba\u764c\u7b5b\u67e5\u7684\u6709\u6548\u6027\uff0c\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u6b27\u76df\u613f\u610f\u8d44\u52a9 iDNA\u53ca\u5176\u7814\u7a76\u4f19\u4f34\u57285\u4e2a\u6b27\u6d32\u56fd\u5bb6\u8fdb\u884c\u80ba\u764c\u7b5b\u67e5\u8bd5\u70b9\u9879\u76ee\u3002\u8fd9\u4e2a\u6700\u65b0\u5b9e\u9a8c\u88ab\u547d\u540d\u4e3a\u201c 4-IN-THE-LUNG-RUN\u201d\uff0c\u4ece2020\u5e741\u67081\u65e5\u5f00\u59cb\u5b9e\u65bd\u3002\u66f4\u591a\u6709\u5173\u6b64\u5b9e\u9a8c\u7684\u4fe1\u606f\uff0c<a href=\"https:\/\/i-dna.org\/zh-hans\/4-in-the-lung-run\/\">\u8bf7\u770b\u8fd9\u91cc<\/a>\u3002[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;\u53c2\u8003\u6587\u732e&#8221; tab_id=&#8221;1579027460457-eaea1c4a-9e62&#8243;][vc_column_text]<\/p>\n<ol>\n<li><span style=\"font-weight: 400;\">Ferlay J, Colombet M, Soerjomataram I, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer 2018; 103: 356-87<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66(1): 7-30.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Services. UDoHaH. The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General. . Atlanta: US Department for Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. Bmj 2000; 321(7257): 323-9.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Jeon J, Holford TR, Levy DT, et al. Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach. Ann Intern Med 2018; 169(10): 684-93.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">National Lung Screening Trial Research T, Aberle DR, Adams AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365(5): 395-409.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Henschke CI, McCauley DI, Yankelevitz DF, et al. (1999). Early Lung Action Project: overall design and findings from baseline screening. Lancet. 354(9173):99-105<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Yousaf-Khan U, van der Aalst C, de Jong PA, et al. Final screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval. Thorax. 2017; 72(1): 48-56.<\/span><\/li>\n<li>de Koning HJ, van der Aalst CA, de Jong PA, et al. <span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit;\">Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. New England Journal of Medicine. 2020; published online at NEJM.org. DOI: 10.1056\/NEJMoa1911793<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Goffin JR, Flanagan WM, Miller AB, et al. Biennial lung cancer screening in Canada with smoking cessation-outcomes and cost-effectiveness. Lung Cancer. 2016 Nov;101:98-103. doi: 10.1016\/j.lungcan.2016.09.013. Epub 2016 Sep 28.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Ten Haaf K, Tammema\u00a8gi MC, Bondy SJ, et al. Performance and cost-effectiveness of computed tomography lung cancer screening scenarios in a population-based setting: a microsimulation modeling analysis in Ontario, Canada. PLoS Med. 2017;14:e1002225. [PMID:28170394] doi:10.1371\/journal.pmed.1002225<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Horeweg N et al. Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial. (2013). Eur Respir J. 42(6):1659-67.<\/span><\/li>\n<li>De Koning H, Van Der Aalst C, Ten Haaf K, et al: Effects of volume CT lung cancer screening: Mortality results of the NELSON randomized-controlled population based trial. 2018 World Conference on Lung Cancer.\u00a0<a href=\"https:\/\/library.iaslc.org\/conference-program?product_id=10\" target=\"_blank\" rel=\"noopener noreferrer\">Abstract PL02.05<\/a>. Presented September 25, 2018.<\/li>\n<li>Slatore CG, Baumann C, Pappas M, Humphrey LL. Smoking behaviors among patients receiving computed tomography for lung cancer screening. Systematic review in support of the U.S. preventive services task force. Ann Am Thorac Soc 2014; 11(4): 619-27.<\/li>\n<li>Ferlay J, Colombet M, Soerjomataram I, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer 2018; 103: 356-87.<\/li>\n<li>Tanner NT, Kanodra NM, Gebregziabher M, et al. The Association between Smoking Abstinence and Mortality in the National Lung Screening Trial. Am J Respir Crit Care Med 2016; 193(5): 534-41.<\/li>\n<li><span style=\"font-weight: 400;\">Tramontano AC, Sheehan DF, McMahon PM, et al. Evaluating the impacts of screening and smoking cessation programmes on lung cancer in a high-burden region of the USA: a simulation modelling study. BMJ Open 2016; 6(2): e010227.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">de Koning H.J., van der Aalst C.M., ten Haaf K., Oudkerk M. PL02.05 &#8211; Effects of Volume CT Lung Cancer Screening: Mortality Results of the NELSON Randomised-Controlled Population Based Trial. 19th World Conference on Lung Cancer. Toronto, Canada; 2018.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Pinsky PF, Church TR, Izmirlian G, Kramer BS. The National Lung Screening Trial: results stratified by demographics, smoking history, and lung cancer histology. Cancer 2013; 119(22): 3976-83.<\/span><\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion]<div class=\"grve-empty-space grve-height-1x\" style=\"\"><\/div>[\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/5&#8243;][\/vc_column][vc_column width=&#8221;1\/5&#8243;][\/vc_column][vc_column width=&#8221;1\/5&#8243;]<h3 class=\"grve-element grve-title grve-align-left grve-h2\" style=\"\"><span><br \/>\n\u89e3\u51b3\u65b9\u6848<br \/>\n<\/span><\/h3>[\/vc_column][vc_column width=&#8221;1\/5&#8243;][\/vc_column][vc_column width=&#8221;1\/5&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;]<div class=\"grve-empty-space grve-height-1x\" style=\"\"><\/div><div class=\"grve-element grve-box-icon grve-medium grve-top-icon grve-align-center\" style=\"\"><a href=\"https:\/\/i-dna.org\/zh-hans\/%e8%a7%a3%e5%86%b3%e6%96%b9%e6%a1%88-%e9%9d%a2%e5%90%91%e5%86%b3%e7%ad%96%e8%80%85\/\" title=\"\u9762\u5411\u51b3\u7b56\u8005\"><div 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